Small Changes in Hydration Determine Cephalosporinase Activity of OXA-48 β-Lactamases
نویسندگان
چکیده
منابع مشابه
Heterogeneous hydrolytic features for OXA-48-like β-lactamases.
OBJECTIVES Carbapenem-hydrolysing class D β-lactamases of the OXA-48 type are increasingly reported from Enterobacteriaceae. β-Lactamase OXA-48 hydrolyses penicillins very efficiently, but carbapenems only weakly and spares broad-spectrum cephalosporins. Recently, diverse OXA-48-like β-lactamases have been identified worldwide (OXA-162, OXA-181, OXA-163, OXA-204 and OXA-232). They differ by few...
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INSERM U914 ‘Emerging Resistance to Antibiotics’, K.-Bicêtre, France; LabEx LERMIT, Faculté de Médecine Paris Sud, K.-Bicêtre, France; Centre National Associé-Centre de Référence des Résistances aux Antibiotiques, K.-Bicêtre, France; Medical and Molecular Microbiology, Department of Medicine, Faculty of Science, University of Fribourg, Fribourg, Switzerland; HFR-Hôpital Cantonal, Fribourg, Swit...
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Laurent Dortet, Thierry Naas Associated French National Reference Center for Antibiotic Resistance, Le Kremlin-Bicêtre, France; Research Unit EA7361 “Structure, Dynamic, Function and Expression of Broad Spectrum β-Lactamases,” Faculty of Medicine, University Paris-Sud, Le Kremlin-Bicêtre, France; Department of Bacteriology-Parasitology-Hygiene, Bicêtre Hospital, Assistance Publique—Hôpitaux de ...
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Jorge L. M. Sampaio, Vanessa B. Ribeiro, Juliana Coutinho Campos, Franciéli P. Rozales, Cibele M. Magagnin, Diego R. Falci, Renato Cassol F. da Silva, Micheline G. Dalarosa, Daniela I. Luz, Fabiane J. Vieira, Laura C. Antochevis, Afonso Luis Barth, Alexandre P. Zavascki Departamento de Análises Clínicas e Toxicológicas—Faculdade de Ciências Farmacêuticas, Universidade de São Paulo, São Paulo, B...
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ژورنال
عنوان ژورنال: ACS Catalysis
سال: 2020
ISSN: 2155-5435,2155-5435
DOI: 10.1021/acscatal.0c00596